Best Computer Mouse For Large Hands in 2022 [*Top Picks*]

Looking for the best computer mouse for large hands on the market? We’ve got you covered. Check out our ratings of absolute bestsellers below and make a final decision.

4671 Reviews Scanned

  • Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized Hands, 2-Year Battery, Silent Clicks, Customizable Side Buttons, Bluetooth, Multi-Device Compatibility - Black
    Bestseller #1
    Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized Hands, 2-Year Battery, Silent Clicks, Customizable Side Buttons, Bluetooth, Multi-Device Compatibility - Black (386)
      Scroll smarter: With Logitech Signature M650 Wireless Mouse you get line-by-line precision for documents and super-fast scrolling for long web pages; simply switch modes with a flick of the SmartWheel The optimal fit for your hand: This comfortable full size mouse is designed for larger hands, for the optimal fit Upgrade your comfort: This work mouse provides long hours of comfort thanks to a contoured shape, soft thumb area, and rubber side grips that keep your hand snug and in place Connect the way you like: Connect this cordless computer mouse in an instant via Bluetooth Low Energy or Logi Bolt USB receiver Less noise, more focus: Whether working at the office or at home, Logitech Signature M650 is a quiet mouse, allowing you to enjoy 90 percent less click noise with SilentTouch technology* Customizable side buttons: Customize the side buttons on the computer mouse with Logitech Options+, available on Windows and macOS, to your favorite shortcuts – like back/forward or copy/paste 24 month battery life: Work for up to 2 years on the single AA battery that comes with your multi-device mouse** Works on multiple platforms: Experience seamless compatibility with Windows, macOS, Linux, Chrome OS, ipadOS, and Android operating systems with Logitech Signature M650 wireless Bluetooth mouse
  • Amazon Basics Full-Size Ergonomic Wireless PC Mouse with Fast Scrolling
    Bestseller #1
    Amazon Basics Full-Size Ergonomic Wireless PC Mouse with Fast Scrolling (386)
      Full-size wireless mouse with fast-scrolling, clickable wheel and forward/back thumb buttons for fast, easy navigating through large documents and web pages Ergonomically designed for right-handed users; smooth, gently curved profile fits perfectly in the palm of the hand for enhanced comfort 2.4 GHz (non-bluetooth) wireless connection; uses a small USB receiver that can stay plugged into your computer without obstructing other ports Optical sensor (1600 DPI resolution) works on most surfaces; uses 2 AA batteries (included); battery LED light and on/off switch for extended battery life Compatible with Windows 7, 8, and 10; backed by an Amazon Basics 1-year limited warranty
  • Wired Vertical Mouse, Optical Ergonomic Mouse with 4 Adjustable DPI 800/1200/2000/3200, 5 Buttons USB Computer Mouse , Better for Large and Medium Sized Hands
    Bestseller #1
    Wired Vertical Mouse, Optical Ergonomic Mouse with 4 Adjustable DPI 800/1200/2000/3200, 5 Buttons USB Computer Mouse , Better for Large and Medium Sized Hands (25)
      【Ergonomic Design】-Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. (Note: it is a right-handed mouse) 【More Adjustment】-800 / 1200 / 2000 / 3200 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces. 【Useful Page Buttons】-Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer. 【No Deed for Battery】-Plug and Play mouse with USB 2.0 interface, easy to start to use with standard setting function. High quality rubber coating surface gives it a feel-good touch 【Wide compatibility】-Compatible with Windows 7/8/10 / Vista / XP / 2000, Mac OS, Linux (NOTE: the forward and backward buttons are not recognized on Mac). Plug and play.
  • Logitech M510 Wireless Computer Mouse for PC with USB Unifying Receiver - Graphite
    Bestseller #1
    Logitech M510 Wireless Computer Mouse for PC with USB Unifying Receiver - Graphite (386)
      Your hand can relax in comfort hour after hour with this ergonomically designed mouse. Its contoured shape with soft rubber grips, gently curved sides and broad palm area give you the support you need for effortless control all day long. You’ve got the control to do more, faster. Flipping through photo albums and Web pages is a breeze, especially for right-handersβ€”with three standard buttons plus Back/Forward buttons that you can also program to switch applications, go full screen and more. And side-to-side scrolling plus zoom gives you the power to scroll horizontally and vertically through your music library, maps and Facebook feeds, and zoom in and out of photos and budget spreadsheets with a click. 2 years of battery life practically eliminates the need to replace batteries. The On/Off switch helps conserve power, smart sleep mode extends battery life and an indicator light eliminates surprises. The tiny Logitech Unifying receiver stays in your laptop. There’s no need to unplug it when you move around, so there’s less worry of it being lost. And you can easily add compatible wireless mice and keyboards to the same wireless receiver.
  • Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite
    Bestseller #1
    Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite (151)
      ADVANCED ERGONOMIC DESIGN - Places your hand in a natural handshake position using a unique 57-degree angle, preventing forearm twisting and reducing muscular strain by 10 percent (As compared with a traditional non-vertical mouse. Based on Logitech Study, September 2017) HYPER-EFFICIENT TRACKING - 4000 DPI high-precision sensor provides precise tracking that requires 4x less hand movement compared to a traditional mouse with a 1000 DPI sensor CROSS-COMPUTER CONTROLΒ - Game-changing capacity to navigate seamlessly on three computers, and copy-paste text, images, and files from one to the other using Logitech FLOW THREE WAYS TO CONNECTΒ - Use with up to three Windows or Mac computers via included wireless USB unifying receiver or Bluetooth smart technology or the included USB-C charging cable RECHARGEABLE BATTERY - With quick charging: Stays powered for 4 months on a full charge – and get 3 hours of use from a 1-minute quick charge (Battery life may vary based on user and computing conditions)
  • Logitech M525 Wireless Mouse – Long 3 Year Battery Life, Ergonomic Shape for Right or Left Hand Use, Micro-Precision Scroll Wheel, and USB Unifying Receiver for Computers and Laptops, Black/Gray
    Bestseller #1
    Logitech M525 Wireless Mouse – Long 3 Year Battery Life, Ergonomic Shape for Right or Left Hand Use, Micro-Precision Scroll Wheel, and USB Unifying Receiver for Computers and Laptops, Black/Gray (386)
      ERGONOMIC SHAPE - Ergonomically shaped design and soft rubber grips conform to your hand to be naturally comfortable and the compact size makes it easy to take with you wherever you use your computer at home, at work or anywhere else, USB receiver is stored inside the mouse where the batteries are located Interface: USB receiver. Mouse Dimensions (height x width x depth)-4.00 x 2.24 x 1.51 inches. Receiver Dimensions (height x width x depth)-0.57 x 0.74 x 0.24 inches CONVENIENT CONTROLS - Easy-to-reach Back/Forward buttons makes moving quickly between documents or browsing your favorite Web sites a breeze MICRO-PRECISE SCROLL WHEEL - With more grooves per millimeter, our new scroll wheel gives you the ultimate navigation experience LONG BATTERY LIFE - 3 year battery life and smart sleep mode help you go longer between battery changes PLUG'N'PLAY CONNECTION - Nano-sized Logitech wireless unifying receiver stays in your computer plug it in, forget it, even add compatible wireless devices without multiple USB receivers
  • Wireless Mouse 700mAh INPHIC Large Ergonomic Rechargeable 2.4G Optical PC Laptop Cordless Mice with USB Nano Receiver, for Windows Computer Office, Black
    Bestseller #1
    Wireless Mouse 700mAh INPHIC Large Ergonomic Rechargeable 2.4G Optical PC Laptop Cordless Mice with USB Nano Receiver, for Windows Computer Office, Black (1210)
      πŸ”‹ Rechargeable Wireless Mouse: Built-in 700mAh high quality rechargeable battery means you can recharge whenever you want. When you leave your mouse more than 5 minutes, it will automatically get into sleep mode which saves electricity of the mouse, and click any button for waking up the mouse again (P.S. Please recharge for 1 hour when the mouse is new before use). πŸ”‡ Silent Click: Silent clicking laptop mouse for left and right button fits the circumstance for using the mouse in public, such as library, dormitory, office and so on, and apart from blue light indication during recharging and light off after full recharge, this design results worry-free for disturbing others πŸ’― 2.4GHz Nano USB Mouse: Stable connection up to 10-meter working distance and just simply insert the nano USB and play; 3 adjustable DPI (1000/1200/1600) for freely controlling mouse speed πŸ‘ 6 High Efficient Buttons: There are not only clickless left and right buttons, but also a DPI adjusting button, scroll wheel and two side buttons. The function of the side buttons is to help you to back or forward when you browse a website, a USB mouse with side buttons is more convenient for you surfing and working 🀞 1-Year Warranty & Wide Compatibility: This wireless mouse is compatible with Windows 7/8/10/XP, Vista and Mac OS system and under the following warranty policy, 45-day unconditional refund and 12 months repairing warranty
  • AUTLEY Wired Ergonomic Mouse, USB Computer Vertical Mouse, 1000/1600/2400/3200 DPI, 5.9ft Cord, Better for Large Hands (M19W)
    Bestseller #1
    AUTLEY Wired Ergonomic Mouse, USB Computer Vertical Mouse, 1000/1600/2400/3200 DPI, 5.9ft Cord, Better for Large Hands (M19W) (46)
      【Superior ergonomic design for Healthy Work】The practical ergonomic shape closely supports the palm, the proper vertical design that keeps the hand and arm in a more natural way. Effectively reduces the strain and pain of the wrist compared to a normal mouse. (Note: it is a right-handed mouse) 【Large size】The size of AUTLEY wired ergonomic mouse fits well for men's hands (large hands), maybe NOT very comfortable for women or small hands. It will take several days to get used to. 【Four different sensitivities】1000/1600/2400/3200 DPI, switchable with the DPI button. Used for regular office work, casual games, study, graphic design etc. 【Wide compatibility】Compatible with Windows 8/7/10 / Vista / XP / 2000, Mac OS, Linux (NOTE: the forward and backward buttons are not recognized on Mac). Plug and play. 【Our Service】- At AUTLEY, you will get 90 Day Money-back Guarantee, 1-Year Warranty(365-day replacement service) and Lifetime technical support. If any issue with this mouse, please contact us for a free replacement or full refund. We'll reply to you within 24-hour.
  • Logitech M510 Wireless Mouse-Black (Renewed)
    Bestseller #1
    Logitech M510 Wireless Mouse-Black (Renewed) (221)
      This Certified Refurbished product is tested & certified to work like-new. The product is backed by a 90 day warranty Contoured shape with soft rubber grips provide all-day comfort Back/forward buttons and side-to-side scrolling plus zoom let you do more, faster Requires Logitech SetPoint software 2-year battery life practically eliminates the need to replace batteries Battery life may vary based on user and computing conditions Comes with a tiny Logitech Unifying receiver that stays in your computer - plug it in, forget it
  • J-Tech Digital Wired Ergonomic Vertical USB Mouse with Adjustable Sensitivity (600/1000/1600 DPI), Scroll Endurance, Removable Palm Rest & Thumb Buttons [V628]
    Bestseller #1
    J-Tech Digital Wired Ergonomic Vertical USB Mouse with Adjustable Sensitivity (600/1000/1600 DPI), Scroll Endurance, Removable Palm Rest & Thumb Buttons [V628] (689)
      π„π‘π†πŽππŽπŒπˆπ‚ πƒπ„π’πˆπ†π – Designed to be utilized in neutral "handshake" wrist and arm positions for smoother movement and less overall strain helping alleviate wrist pain. π‘π„πŒπŽπ•π€ππ‹π„ ππ€π‹πŒ 𝐑𝐄𝐒𝐓 & 𝐁𝐋𝐔𝐄 𝐋𝐄𝐃 π“π‘πˆπŒ – This mouse comes included with a palm rest that can be easily detached based on the user's preference and convenience. It also features a blue LED, which lights up the outlining of the mouse. 𝐀𝐃𝐉𝐔𝐒𝐓𝐀𝐁𝐋𝐄 πƒππˆβ€“ Switch between DPI levels 800, 1200 and 1600 to adjust mouse responsiveness depending on your need and/or preference. Optical Tracking Technology ensures greater sensitivity for precise tracking on a wide range of surfaces. π“π‡π”πŒπ ππ”π“π“πŽππ’ – Use the back/forward buttons located near the thumb area for optimum convenience, (button functionality can also be changed and reassigned using a compatible driver or software). π–πˆπƒπ„ π‚πŽπŒππ€π“πˆππˆπ‹πˆπ“π˜ & 𝐅𝐑𝐄𝐄 π‹πˆπ…π„π“πˆπŒπ„ π’π”πππŽπ‘π“ – Compatible with Windows 7/8/10, XP, Vista 7/8 and Linux etc. All J-Tech Digital Products include a One-Year Manufacturer Warranty and free lifetime technical support from our Customer Support Team located in Houston, Texas - Available M-F 9AM-6PM CST - Contact information available on the J-Tech Digital Seller Page.
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